ChatGPT’s Limitations in Clinical Research: A Call for Advanced AI

ChatGPT comparison with TrialHub for the clinical research industry

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In the clinical research industry, AI like ChatGPT and Bard, built on large language models (LLMs), have emerged as tools, used to derive information with efficiency. Yet, data accuracy is not their strongest suit. LLMs have the potential to empower clinical researchers by swiftly processing extensive data, spotlighting nuanced patterns such as rare disease prevalence or unexpected side effects within medical records. Additionally, these models can pinpoint novel biomarkers or potential therapeutic targets. The integration of AI promises a transformative shift in clinical research, optimizing both its efficiency and efficacy. However, it must be done specifically with the industry in mind. 

TrialHub vs. ChatGPT in Clinical Research

This is why this article delves into a comprehensive comparison between two notable AI tools: TrialHub IQ, a robust platform designed specifically for clinical research, and ChatGPT, OpenAI’s expansive general-purpose chatbot. With a spotlight on their functionalities, strengths, and limitations, our analysis will provide insights into which tool serves the niche requirements of clinical research more effectively.

Data Sources

ChatGPT: ChatGPT is trained on a broad spectrum of internet information which is more generalist and not tailored to specific applications such as clinical research. Thus, while boasting a broad knowledge base, its sources might vary in credibility.

TrialHub IQ: Built specifically for clinical research and the medical field, its data sources include 20 million peer-reviewed PubMed articles and 2,000 medical guidelines. It also supports the capability to include company proprietary data that can either be queried on its own or can be blended with other public sources allowing its you to generate truly unique insights. As a result, the answers provided are rooted in highly vetted, up-to-date, and credible medical knowledge.

Relevance & Specificity

ChatGPT: Given its general training set, answers might not always match the precision that a specialized system like TrialHub IQ offers, particularly for nuanced medical inquiries.

TrialHub IQ: Its retrieval mechanism enables it to fetch relevant excerpts from medical articles, ensuring answers are directly tied to specific research. 

Information Traceability

ChatGPT: Lacks direct references, so you can’t trace the information to a definite article or study.

TrialHub IQ: Answers can be linked directly to particular medical articles, letting you track back to original sources. Providing access to sources allows you to verify the accuracy and credibility of the information, promoting transparency and accountability which is what TrialHub stands for. Additionally, it empowers you to delve deeper into topics, encourages critical thinking, and facilitates learning by offering a pathway to explore the context and background of the provided information. Ultimately, source visibility enhances the overall quality of the user experience and helps you make well-informed decisions.

Depth & Breadth of Knowledge

ChatGPT: While knowledgeable across various topics, its depth in specialized medical domains might not be as extensive as TrialHub IQ.

TrialHub IQ: Exhibits profound medical knowledge, especially since it is consistently updated with new medical research, from verified sources.

Incorporation of Proprietary Data Files

ChatGPT: ChatGPT’s model doesn’t include a feature for the direct incorporation of proprietary data files. It operates based on a fixed model and doesn’t allow you to enhance its knowledge base with proprietary data.

TrialHub IQ: Provides the capability to incorporate you’ proprietary data files, enhancing its knowledge base with specialized information while maintaining strict confidentiality and security standards to protect sensitive data. This feature empowers you to gain exceptionally specialized insights from their own, proprietary data.

Update Frequency

ChatGPT: Its knowledge remains static post-training, meaning it might not capture new medical findings post its latest update.

TrialHub IQ: With its design centered around clinical research, it offers more contemporary medical details. TrialHub’s database gets updated in real time and is double-checked by an international team of medical experts. 

The Expert’s View

Dr. Tony Perez, a consultant for pharma companies, with 30+ years of extensive knowledge in the world of clinical development, shares his personal experiences with ChatGPT & TrialHub: “I’ve tested ChatGPT, and my interactions varied. For instance, when I inquired about the ‘overall survival in chordoma,’ the response was fair. However, for more intricate questions related to clinical trials, it sometimes fell short of my expectations.” His detailed feedback reveals both the strengths and limitations of ChatGPT in the context of clinical research.

Dr. Perez further highlighted, “For me, everything related to diseases and treatment quickly tabulated in terms of competitors, phases of development, etc. TrialHub will be of immense help. Currently, everything has to be done manually. We often find ourselves searching for a needle in a haystack.”


For clinical research needs, TrialHub IQ stands out due to its precision, traceability, and depth of vetted medical information. ChatGPT, on the other hand, with its broad knowledge base, caters to a wider audience but might not always align with the specialized needs of clinical researchers.

The emergence of artificial intelligence in clinical research brings forth platforms tailored to niche requirements. While general tools like ChatGPT offer breadth, specialized platforms like TrialHub provide the depth and precision that professionals in the field often seek. As AI continues to evolve, it’s crucial for you to pick the tool that aligns best with their specific needs.

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